Absorption growth hormone after subcutaneous administration is 80%, the maximum plasma concentration is achieved in 3-6 hours. It penetrates well perfused organs, particularly the liver and kidneys. The volume of distribution of somatropin primobolan depot. The half-life after subcutaneous administration is 3-5 hours.
Stunting in children due to insufficient secretion of growth hormone, with Turner’s syndrome, chronic renal insufficiency (decreased kidney function for more than 50%) in the prepubertal period.
In adults with confirmed congenital or acquired pronounced growth hormone deficiency as a replacement therapy.
Hypersensitivity, malignant neoplasms, urgent conditions (including conditions after surgeries on the heart, the abdomen, acute respiratory failure). Stimulation of growth in patients with closed epiphyseal growth zones: Pregnancy and breast-feeding (at the time of treatment should abandon breastfeeding).
diabetes mellitus, cranial hypertension, hypothyroidism, concomitant therapy with glucocorticosteroids, hypothyroidism (including the replacement therapy with thyroid hormones), Prader-Willi syndrome.
Dosing and Administration
Primobolan depot is administered subcutaneously, slowly, 1 times a day, usually at night. Injection sites should be changed for the prevention of the development of lipoatrophy.
Dissolve contents of vial recommended supplied in 1 ml of solvent, calculated based on the dose. To this solvent was selected syringe and injected into the vial through the stopper. Gently shake the vial until complete dissolution of the content. Sudden shaking at the same time is unacceptable. The prepared solution is kept in the bottle up to two weeks at a temperature of 2 ° C to 8 ° C.
Doses picked individually, taking into account the severity of growth hormone deficiency, weight or body surface area, the effectiveness of the therapy.
When growth hormone deficiency in adults is an initial dose of 0.15-0.3 mg / day. (corresponding 0,45-0,9 IU / day.), followed by its increase, depending on the effect. In titration dose level of insulin-like growth factor (IGF-I) in the blood serum can be used as a benchmark. The maintenance dose is adjusted individually, but does not exceed, as a rule, 1 mg / day, which corresponds to 3 IU / day. Older recommended lower doses.
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Increased intracranial pressure (headache, nausea, vomiting, blurred vision), decreased thyroid function, hyperglycemia, leukemoid primobolan depot reaction epiphysiolysis femoral head, fluid retention with the development of peripheral edema. The symptoms are usually transient, dose-dependent, may require dose reduction. Local reactions:. Lipoatrophy, pain, and itching at the injection site Attention: The following side effects have been described in the literature with the use of somatropin product: weakness, fatigue, gynecomastia, papilledema (usually occurs within the first 8 weeks of treatment, most often in patients with Turner’s syndrome), pancreatitis (abdominal pain, nausea, vomiting), otitis media and hearing loss (in patients with Turner’s syndrome), subluxation of the hip in children (limping, pain in the hip and knee), gynecomastia, growth acceleration preexisting nevus (possible malignancy), the progression of scoliosis (in patients with overgrowth), elevated levels of inorganic phosphate in the blood, parathyroid hormone, and alkaline phosphatase activity. online anabolic steroids pharmacy
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